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Multiple Myeloma

Multiple Myeloma is a type of blood cancer that affects plasma cells, a type of white blood cells (WBC). These WBC's are part of your immune system, which helps protect the body from germs and other harmful pathogens. In multiple myeloma, the malignant overgrowth of plasma cells in the bone marrow can simply crowding out the normal plasma cells. These malignant plasma cells then produce an abnormal antibody known as M protein, which offers no benefit to the body and may cause tumors, kidney damage, bone destruction, and impaired immune function. The hallmark characteristic of multiple myeloma is a high level of M protein in the blood.

There are, however, other plasma cell disorders that also have abnormal plasma cells but do not meet the criteria to be called active multiple myeloma. These other plasma cell disorders include:

  • Monoclonal gammopathy of uncertain significance (MGUS)
  • Smouldering multiple myeloma (SMM)
  • Solitary plasmacytoma
  • Light chain amyloidosis.

No one knows the exact causes of multiple myeloma, but it is more common in older people and African Americans. It can run in families. Common symptoms may include:

  • Bone pain, often in the back or ribs
  • Broken bones
  • Weakness or fatigue
  • Weight loss
  • Frequent infections and fevers
  • Feeling very thirsty
  • Frequent urination

Doctors diagnose multiple myeloma using:

  • Lab tests
  • Imaging tests
  • Bone marrow biopsy

Your treatment depends on how advanced the disease is and whether you have symptoms. 
If you have symptoms, you may have chemotherapy, stem cell transplantation, radiation, or targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells.

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Stem cell transplant for Multiple Myeloma

A stem cell transplant or a bone marrow transplant is a procedure to replace your diseased bone marrow with healthy bone marrow. A bone marrow transplant, in combination with chemotherapy, is a treatment option that offers a better chance for durable remission for people with multiple myeloma. Because the chemotherapy attacks all the blood cells in the bone marrow—not just the multiple us myeloma cells—a stem cell transplant provides the body with a new source of healthy cells.

Bone marrow transplants are no longer done in multiple myeloma. Instead, almost all transplants in multiple myeloma are now obtained from the blood and are referred to as peripheral blood stem cell transplants.

There are generally two types of stem cell transplant performed for multiple myeloma: 

  • Autologous stem cell transplant, which uses the patient’s own stem cells
  • Allogeneic stem cell transplant, which uses stem cells from a donor
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Top Doctors In India For Stem cell transplant for Multiple Myeloma

Dr. Sushant Mittal

10 years of experience , New Delhi, Delhi/NCR, India

Dr. Samit Purohit

10 years of experience , New Delhi, Delhi/NCR, India

Dr. Chandragouda Dodagoudar

18 years of experience , New Delhi, Delhi/NCR, India

Dr. Anil Kumar Anand

36 years of experience , New Delhi, Delhi/NCR, India